SAB5700522
Anti-Phospho-STAT5-Y694 antibody produced in rabbit
Synonym(s):
MGF, STAT5, stat5a/stat5b
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About This Item
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human, rat, mouse
Application:
IHC, WB
Citations:
-
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
90
species reactivity
human, rat, mouse
concentration
2.75 mg/ml
technique(s)
immunohistochemistry: 1:100-1:200, western blot: 1:500-1:2000
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr694)
Quality Level
Gene Information
human ... STAT5(6776)
General description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Immunogen
A phospho specific peptide corresponding to residues surrounding Y694 of human STAT5.
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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