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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
7Z8X9, monoclonal
Application:
—
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
7Z8X9, monoclonal
form
liquid
mol wt
53 kDa
Quality Level
Gene Information
human ... TP53(7157)
concentration
0.90 mg/mL
color
colorless
isotype
IgG
immunogen sequence
HKKLM
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Immunogen
A synthetic acetylated peptide around K382 of human p53 (NP_000537.3).
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Application
DB, WB
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 3
Regulatory Information
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