SAB5702157
Anti-Notch1 Antibody, clone 7L3V4, Rabbit Monoclonal
Synonym(s):
AOS5,AOVD1,TAN1,hN1,NOTCH1,Activated NOTCH1,notch 1
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
7L3V4, monoclonal
Application:
IP, WB
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
7L3V4, monoclonal
form
liquid
mol wt
125 kDa
Quality Level
Gene Information
human ... NOTCH1(4851)
concentration
2 mg/mL
technique(s)
immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
ILPQESPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNVSDWSEGVSSPPTSMQSQIARIPEAFK
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Immunogen
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
A synthetic peptide corresponding to a sequence within amino acids 2456-2555 of human Notch1 (P46531).
Application
WB, IP
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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