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Merck
CN

SAB5702201

Anti-IL1β Antibody, clone 7E1S4, Rabbit Monoclonal

Synonym(s):

IL-1,IL1-BETA,IL1F2,IL1 beta,IL1B

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About This Item

NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
7E1S4, monoclonal
Application:
IF, WB
Citations:
-

Key Documents

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biological source

rabbit

conjugate

unconjugated

material

colorless

clone

7E1S4, monoclonal

form

liquid

mol wt

35 kDa

Quality Level

100

Gene Information

human ... IL1B(3553)

concentration

0.5 mg/mL

technique(s)

immunofluorescence: 1:50 - 1:200, western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

immunogen sequence

APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

UniProt accession no.

P01584

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

Immunogen

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 117-269 of human IL1β (NP_000567.1).

Application

WB, IF/ICC

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

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