SAB5702422
Anti-Chk1 Antibody, clone 0S3Q1, Rabbit Monoclonal
Synonym(s):
CHK1
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
0S3Q1, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human
Citations:
Technique(s):
immunohistochemistry: 1:50 - 1:200
western blot: 1:500 - 1:2000
western blot: 1:500 - 1:2000
Uniprot accession no.:
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
0S3Q1, monoclonal
form
liquid
mol wt
55 kDa
species reactivity
human
concentration
0.53 mg/mL
technique(s)
immunohistochemistry: 1:50 - 1:200
western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDI
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHEK1(1111)
Immunogen
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Chk1 (O14757).
Application
WB, IHC
General description
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
常规特殊物品
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