SAB5702607
Anti-ESRα Antibody, clone 4L8K5, Rabbit Monoclonal
Synonym(s):
ESR1,ER,ESR,ESRA,ESTRR,Era,NR3A1,ER alpha
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
4L8K5, monoclonal
Application:
IF, WB
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
4L8K5, monoclonal
form
liquid
mol wt
66 kDa
concentration
1.33 mg/mL
technique(s)
immunofluorescence: 1:50 - 1:200, western blot: 1:1000 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
AVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFY
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ESR1(2099)
species reactivity
human
General description
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Estrogen Receptor alpha (ESRα) (P03372).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IF/ICC
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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