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About This Item
UNSPSC Code:
51111800
NACRES:
NA.43
biological source
mouse
recombinant
expressed in CHO cells
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
clone
SAA0282, recombinant monoclonal
assay
>95% (SDS-PAGE)
form
liquid
mol wt
150 kDa
species reactivity
monkeypox virus
concentration
1 mg/mL
technique(s)
ELISA: 1:2000-1:4000
neutralization: 0.01-10 μg/mL
color
colorless
pH
7.4
isotype
IgG2a, kappa
Protein ID accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
-65 to -96°C
target post-translational modification
unmodified
Quality Level
Application
ELISA,neutralization
Biochem/physiol Actions
Monoclonal Anti-Monkeypox virus/MPXV H3L Antibody, clone SAA0282 is highly specific and bind to the H3L protein of the virus. This binding inhibits the virus from entering cells, thus preventing infection. The antibodies also trigger the body’s immune system to produce anti-viral proteins that can clear the virus from the body.
General description
Anti-Monkeypox virus/MPXV H3L Antibody, clone SAA0282 is produced in mouse. The monoclonal antibodies are IgG immunoglobulins, which consist of two heavy chains and two light chains. Each heavy chain contains four domains, and each light chain contains two domains. The antibody binds to the antigen of the monkeypox virus, which is the H3L protein.
Monkeypox virus (MPXV), like smallpox virus, belongs to the genus Orthopoxvirus. Its morphology is consistent with that of orthopoxvirus, with a brick-shaped or oval shape with rounded corners and a size of 200~400nm. Brick-shaped or oval-shaped, covered by a lipoprotein membrane or envelope, with two protein-containing side bodies in the middle, and a thick membrane core containing a large double-stranded DNA gene body. The genome of Mpox virus is a double-stranded DNA, about 197kb long, and the end of the genome contains an identical but opposite terminal inverted repeat sequence. The virus contains 190 open reading frames, 4 of which are located in terminal inverted repeats. The core proteins of monkeypox virus are A29L, A35R, B6R, M1R, H3L.
Monkeypox virus (MPXV), like smallpox virus, belongs to the genus Orthopoxvirus. Its morphology is consistent with that of orthopoxvirus, with a brick-shaped or oval shape with rounded corners and a size of 200~400nm. Brick-shaped or oval-shaped, covered by a lipoprotein membrane or envelope, with two protein-containing side bodies in the middle, and a thick membrane core containing a large double-stranded DNA gene body. The genome of Mpox virus is a double-stranded DNA, about 197kb long, and the end of the genome contains an identical but opposite terminal inverted repeat sequence. The virus contains 190 open reading frames, 4 of which are located in terminal inverted repeats. The core proteins of monkeypox virus are A29L, A35R, B6R, M1R, H3L.
Packaging
100µg per vial / 1 mg per vial
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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