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Merck
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SAB6010096

Sigma-Aldrich

Anti-phospho-LAT (Y191) antibody, clone 2E4, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

Synonym(s):

Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38, LAT

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About This Item

UNSPSC Code:
12352203

Key Documents

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recombinant

expressed in HEK 293 F cells

Quality Level

100

conjugate

unconjugated

antibody product type

primary antibodies

clone

2E4, recombinant monoclonal

form

liquid

mol wt

150 kDa

purified by

affinity chromatography

species reactivity

human

concentration

2.35mg/ml

technique(s)

ELISA: 2000:10000
flow cytometry: 1:50-1:200
immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200

isotype

IgG

UniProt accession no.

O43561

shipped in

wet ice

storage temp.

-10 to -25°C

target post-translational modification

phosphorylation (pTyr191), phosphorylation (pTyr191)

General description

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Immunogen

A synthesized peptide derived from human Phospho-LAT (Y191)

Physical form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Preparation Note

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Other Notes

SRE-pY-VN

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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