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Merck
CN

SAB6012221

Anti RB1 Antibody, clone 23GB2535, Rabbit Monoclonal

newenhanced validation

clone 23GB2535, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

OSRC, P110-RB1, PPP1R130, PRB, Pp110

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB2535, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

106 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

1.5 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000139687

NCBI accession no.

NP_000312.2

UniProt accession no.

P06400

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RB1(5925)

General description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 701-928 of human Retinoblastoma [NP_000312.2].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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