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Merck
CN

SAB6012308

KD-Validated Anti Cystathionine beta-synthase Antibody, clone 23GB3800, Rabbit Monoclonal

newenhanced validation
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clone 23GB3800, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

CBSL, HIP4

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB3800, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

61 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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sustainability

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concentration

0.625 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000160200

NCBI accession no.

NP_000062.1

UniProt accession no.

P35520

greener alternative category

DfS-Developed

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CBS(875)

Related Categories

General description

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
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Immunogen

A synthesized peptide corresponding to a sequence within amino acids 460-500 of human CBS [NP_000062.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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