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Merck
CN

SBR00059

Sigma-Aldrich

Balofloxacin

≥98% (HPLC), powder

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About This Item

Linear Formula:
C20H24FN3O4.2H2O
CAS Number:
UNSPSC Code:
51101500
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

off-white

antibiotic activity spectrum

(anaerobic bacteria)
Gram-negative bacteria
Gram-positive bacteria

Mode of action

DNA synthesis | inhibits

SMILES string

CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F

InChI

1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)

InChI key

MGQLHRYJBWGORO-UHFFFAOYSA-N

General description

Balofloxacin is a broad spectrum synthetic fluoroquinolone antibiotic. It exerts its antibacterial activity by inhibiting DNA gyrase and topoisomerase IV, which are enzymes essential for bacterial DNA synthesis and replication.

Application

One of the main applications of fluoroquinolones like Balofloxacin is their ability to target and inhibit bacterial DNA gyrase and topoisomerase IV, which are enzymes that are essential for bacterial DNA replication and transcription. Because of their potency against these targets, fluoroquinolones have been used as lead compounds for the development of new antibiotics and other drugs that target these enzymes.

Biochem/physiol Actions

Balofloxacin inhibits bacterial DNA synthesis by interfering with the activity of DNA gyrase and topoisomerase IV enzymes, which are necessary for the replication, transcription, and repair of bacterial DNA. Balofloxacin is active against gram-negative, gram-positive, and anaerobic bacteria.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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