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Merck
CN

SCP0012

Calmodulin Dependent Protein Kinase II 281-309

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About This Item

Empirical Formula (Hill Notation):
C146H254N46O39S3
Molecular Weight:
3374.06
NACRES:
NA.32
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

storage temp.

−20°C

Application

Calmodulin Dependent Protein Kinase II 281-309 [CaMK-(281-309)] is a CaMK-peptide used to probe interactions of the various regulatory domains of protein kinase II.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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R J Colbran et al.
The Journal of biological chemistry, 263(34), 18145-18151 (1988-12-05)
Two peptide analogs of Ca2+/calmodulin-dependent protein kinase II (CaMK-(peptides)) were synthesized and used to probe interactions of the various regulatory domains of the kinase. CaMK-(281-289) contained only Thr286, the major Ca2+-dependent autophosphorylation site of the kinase (Schworer, C. M., Colbran
A Ishida et al.
The Journal of biological chemistry, 270(5), 2163-2170 (1995-02-03)
The active 30-kDa chymotryptic fragment of calmodulin-dependent protein kinase II (CaM kinase II), devoid of the autoinhibitory domain, and the enzyme, autothiophosphorylated at Thr286/Thr287, were much more labile than was the original native enzyme. They were markedly stabilized by synthetic



Global Trade Item Number

SKUGTIN
SCP0012-1MG04061826693032