SCP0164
[Gln8,9]-Helodermin
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About This Item
Empirical Formula (Hill Notation):
C176H285N47O49
Molecular Weight:
3843.43
NACRES:
NA.32
UNSPSC Code:
12352209
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥78%
storage condition
protect from light
storage temp.
−20°C
Application
Helodermin is a VIP-secretin-like peptide that acts via vasoactive intestinal peptide (VIP) receptors.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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P Robberecht et al.
Peptides, 9(2), 339-345 (1988-03-01)
The ability of VIP, PHI, secretin, helodermin, and seven N-terminally D-amino monosubstituted VIP and PHI analogs to occupy (125I)iodo-VIP labeled receptors and to activate adenylate cyclase was tested on human lung membranes purified by the method of Schachter et al.
M Hoshino et al.
FEBS letters, 178(2), 233-239 (1984-12-10)
The complete amino acid sequence of helodermin isolated from the venom of Gila monster was elucidated. The peptide was shown to be a basic pentatriacontapeptide amide: His-Ser-Asp-Ala-Ile-Phe-Thr-Gln-Gln-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-Leu-Ala- Leu-Gln-Lys- Tyr-Leu-Ala-Ser-Ile-Leu-Gly-Ser-Arg-Thr-Ser-Pro-Pro-Pro-NH2. A high degree of sequence similarities to secretin/VIP/PHI/(PHM)/GRF from mammal and
A Vandermeers et al.
European journal of biochemistry, 164(2), 321-327 (1987-04-15)
Having previously isolated helodermin, the major peptide like vasoactive-intestinal-peptide and peptide-histidine-isoleucinamide, from the venom of the lizard Heloderma suspectum, we decided on a systematic exploration of all (VIP-PHI)-like peptides present in the venom of another lizard of the Helodermatidae family:
Mitsuteru Akahoshi et al.
The Journal of clinical investigation, 121(10), 4180-4191 (2011-09-20)
Mast cell degranulation is important in the pathogenesis of anaphylaxis and allergic disorders. Many animal venoms contain components that can induce mast cell degranulation, and this has been thought to contribute to the pathology and mortality caused by envenomation. However
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