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Merck
CN

SMB00081

Wogonoside

≥95% (LC/MS-ELSD)

Synonym(s):

5,7-Dihydroxy 8-methoxyflavone 7-glucuronide, Glychionide B, Oroxindin, Wogonin 7-glucuronide

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About This Item

Empirical Formula (Hill Notation):
C22H20O11
CAS Number:
51059-44-0
Molecular Weight:
460.39
NACRES:
NA.25
PubChem Substance ID:
329824759
UNSPSC Code:
12352205
MDL number:
MFCD08704808

Key Documents

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Product Name

Wogonoside, ≥95% (LC/MS-ELSD)

InChI

1S/C22H20O11/c1-30-18-13(32-22-17(27)15(25)16(26)20(33-22)21(28)29)8-11(24)14-10(23)7-12(31-19(14)18)9-5-3-2-4-6-9/h2-8,15-17,20,22,24-27H,1H3,(H,28,29)/t15-,16-,17+,20-,22+/m0/s1

SMILES string

COc1c(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc(O)c3C(=O)C=C(Oc13)c4ccccc4

InChI key

LNOHXHDWGCMVCO-NTKSAMNMSA-N

assay

≥95% (LC/MS-ELSD)

form

solid

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

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Biochem/physiol Actions

Wogonoside, a flavanoid, is known for its anti-inflammatory properties. Wogonoside may have therapeutic potential for use in diseases which involve the development of inflammation and angiogenesis through its inhibition of LPS-induced angiogenesis.

General description

Natural product derived from plant source.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
122228183V
122228-183V

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Sujuan Wu et al.
Journal of chromatography. A, 1066(1-2), 243-247 (2005-03-30)
A preparative high-speed counter-current chromatography (HSCCC) method for isolation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi (Huang-qin in Chinese) was successfully established by using ethyl acetate-methanol-1% acetic acid water (5:0.5:5, v/v) as the
Ying Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(20-21), 1820-1826 (2009-06-06)
A specific ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method was developed for the simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin in rat plasma. Chromatographic separation was performed on a C(18) column packed with 1.7 microm particles by a linear
Xiao-Yan Wei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1061-1062, 248-255 (2017-08-02)
A rapid, sensitive, and selective UPLC-TQ-MS/MS method was established and validated for the determination and pharmacokinetic investigation of rhein, coptisine, berberine, palmatine, baicalin and wogonoside from Sanhuang Xiexin Decoction (SXD) extracts. A Waters BEH C
Zhenyu Zhu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(24), 2184-2190 (2010-07-21)
The aim of this study was to compare the pharmacokinetics of baicalin and wogonoside in rats following oral administration of Xiaochaihu Tang (Minor Radix Bupleuri Decoction) and Radix scutellariae extract. Thus, a specific LC-MS method was developed and validated for
R Xiao et al.
Human & experimental toxicology, 36(11), 1169-1176 (2016-12-13)
Wogonoside is the main flavonoid of the traditional Chinese medicinal herb Scutellaria baicalensis Georgi and has been found to induce growth suppression in myelogenous leukemia cells. However, its activity in T acute lymphoblastic leukemia (T-ALL) is still unclear. In this
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