SMB00084
Hypaphorine
≥95% (LC/MS-ELSD)
Synonym(s):
Hypaforin, Lenticin
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About This Item
Empirical Formula (Hill Notation):
C14H18N2O2
Molecular Weight:
246.30
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.25
Assay
≥95% (LC/MS-ELSD)
form
solid
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
C[N+](C)(C)C(Cc1c[nH]c2ccccc12)C([O-])=O
InChI
1S/C14H18N2O2/c1-16(2,3)13(14(17)18)8-10-9-15-12-7-5-4-6-11(10)12/h4-7,9,13,15H,8H2,1-3H3
InChI key
AOHCBEAZXHZMOR-UHFFFAOYSA-N
Related Categories
General description
Hypaphorine is a natural product derived from a plant source. It is an indolic compound, initially isolated from Pisolithus tinctorius, an ectomycorrhizal fungus. This compound is made up of tryptophan and three methyl groups. It is recently identified as one of the components of human milk. Hypaphorinecan also be sourced from marine organisms.
Biochem/physiol Actions
Hypaphorine has demostrated sleep promoting properties by increasing non-rapid eye movement sleep duration for the first hour after it is administered in mice.
Hypaphorine is known to reduce glucose levels in rat models. Along with this, it possesses anti-inflammatory and certain neurological functions.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
涉药品监管产品
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Hypaphorine attenuates lipopolysaccharide-induced endothelial inflammation via regulation of TLR4 and PPAR-g dependent on PI3K/Akt/mTOR signal pathway
Sun H, et al.
International Journal of Molecular Sciences, 18(4), 844-844 (2017)
Hypaphorine is present in human milk in association with consumption of legumes
Keller BO, et al.
Journal of Agricultural and Food Chemistry, 61(31) (2013)
Hypaphorine, an indole alkaloid from Erythrina velutina, induced sleep on normal mice
Ozawa M, et al.
Bioorganic & Medicinal Chemistry Letters, 18(14) (2008)
Competitive antagonism between IAA and indole alkaloid hypaphorine must contribute to regulate ontogenesis
Jambois A, et al.
Physiologia Plantarum, 123(2) (2005)
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