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About This Item
Empirical Formula (Hill Notation):
C24H30O14
CAS Number:
Molecular Weight:
542.49
NACRES:
NA.25
UNSPSC Code:
12352200
MDL number:
InChI
1S/C24H30O14/c1-3-11-12(4-5-35-21(32)10-6-14(26)17(28)15(27)7-10)13(22(33)34-2)9-36-23(11)38-24-20(31)19(30)18(29)16(8-25)37-24/h3,6-7,9,11-12,16,18-20,23-31H,1,4-5,8H2,2H3/t11-,12+,16+,18+,19-,20+,23+,24-/m0/s1
InChI key
SMTKSCGLXONVGL-ZEIULZLQSA-N
form
solid
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
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General description
Natural product derived from plant source.
Biochem/physiol Actions
Cornuside is a secoiridoid glucoside with anti-inflammatory properties through the downregulation of iNOS and COX-2 via NF-kB inhibition.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Shun Zong Song et al.
Bioscience, biotechnology, and biochemistry, 75(4), 656-661 (2011-04-23)
This study elucidated the effects of cornuside on carbon tetrachloride (CCl₄)-induced hepatotoxicity. Rats were treated intraperitoneally with 0.5 mL/kg of CCl₄. Sixteen h after CCl₄ treatment, the levels of serum aminotransferases, tumor necrosis factor-α (TNF-α), and lipid peroxidation were significantly
Wang-Lin Jiang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(4), 266-271 (2010-08-27)
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis SIEB. et ZUCC. In this study, we investigated the anti-myocardial ischemia and reperfusion (I/R) injury effects of cornuside in vivo and elucidated the potential mechanism. Rat models of
Wang-Lin Jiang et al.
Pharmacology, 84(3), 162-170 (2009-08-22)
Cornuside, a secoiridoid glucoside compound, was isolated from the fruit of Cornus officinalis Sieb. et Zucc. The present study elucidates the effects of cornuside on cultured rat cortical neuron damage induced by oxygen-glucose deprivation. The results show that cornuside treatment
Dae Gill Kang et al.
Biological & pharmaceutical bulletin, 30(9), 1796-1799 (2007-09-11)
Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. The present study was designed to examine the effects of cornuside on expression levels of cytokine-induced proinflammatory and adhesion molecules in the human umbilical
Dae Gill Kang et al.
Planta medica, 73(14), 1436-1440 (2007-10-11)
Cornuside is a bisiridoid glucoside compound isolated from the fruit of CORNUS OFFICINALIS Sieb. et Zucc. (Cornaceae). In the present study, we investigated the effect of cornuside on vascular tone in rat aortic tissue. Cornuside induced a concentration-dependent relaxation of
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