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Merck
CN

SMB00379

Schisantherin A

≥98% (HPLC)

Synonym(s):

Gomisin C, Schizantherin A, Wuweizi ester A

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About This Item

Empirical Formula (Hill Notation):
C30H32O9
CAS Number:
58546-56-8
Molecular Weight:
536.57
UNSPSC Code:
12352200
PubChem Substance ID:
329824980
NACRES:
NA.25

Key Documents

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SMILES string

CC1(O)C(C)CC2=CC(OCO3)=C3C(OC)=C2C4=C(C=C(OC)C(OC)=C4OC)C1OC(C5=CC=CC=C5)=O

InChI

1S/C30H32O9/c1-16-12-18-13-21-25(38-15-37-21)26(35-5)22(18)23-19(14-20(33-3)24(34-4)27(23)36-6)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3

InChI key

UFCGDBKFOKKVAC-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

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Biochem/physiol Actions

Schisantherin A is a lignan isolated from the fruits of Schisandra chinesi.
Schisantherin A is a mechanism-based inhibitor that competitively inhibits and irreversibly inactivates CYP3A4.
Schisantherin A (StA) has neuroprotective activity and could be potential candidate for the treatment of neuron loss in neurodegenerative diseases including Parkinson′s disease. It inhibits tumor progression and could be a potential drug target for cancer treatment. StA blocks ATP-binding cassette transporters and restores the levels of anti-cancer drugs in cancer cells. It also has anti-inflammatory property.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBN4609V

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Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation.
Liao S, et al.
European Journal of Pharmacology, 780, 65-70 (2016)
Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity.
Liu H W, et al.
European Journal of Medicinal Chemistry, 59, 265-273 (2013)
Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo.
Sa F, et al.
Neuroscience Letters, 593, 7-12 (2015)
Bin Li et al.
Experimental animals, 67(4), 451-461 (2018-05-29)
Schisantherin A (SinA), one of the most abundant active ingredients of Schisandra chinensis, was reported to protect and benefit the liver, however, its effect on alcohol-induced liver injury (ALI) was still not clear. In the present study, an ALI mice
Schisandra Chinensis-derived antioxidant activities in `Sheng Mai San?a compound formulation, in vivo and in vitro.
Ko K M, et al.
Phytotherapy Research, 9(3), 203-206 (1995)
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