Skip to Content
Merck
CN

SMB00505

Sigma-Aldrich

Echinocystic acid

≥95%

Synonym(s):

3β,16α-dihydroxyolean-12-en-28-oic acid

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C30H48O4
CAS Number:
510-30-5
Molecular Weight:
472.70
MDL number:
MFCD00017295
UNSPSC Code:
12352200
PubChem Substance ID:
329825032
NACRES:
NA.25

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Assay

≥95%

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

InChI

1S/C30H48O4/c1-25(2)14-15-30(24(33)34)19(16-25)18-8-9-21-27(5)12-11-22(31)26(3,4)20(27)10-13-28(21,6)29(18,7)17-23(30)32/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20-,21+,22-,23+,27-,28+,29+,30+/m0/s1

InChI key

YKOPWPOFWMYZJZ-PRIAQAIDSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Echinocystic acid (EA) is a natural triterpene acid derivative. Its dehydrogenation in the presence of selenium has been reported. It has been reported to induce programmed cell death in human HepG2 (human hepatocellular liver carcinoma cell line) cells and human promyelocytic leukemia cells (HL-60). Due to its anticancer action, it is widely used in herbal medicines. EA undergoes oxidation in the presence of chromic acid to afford lactone of 3:12:16-triketo-13-hydroxyoleananonic acid. EA has been reported to be present in the bark and leaves of Pithecellobium dulce.
Echinocystic acid is an active component of Codonopsis lanceolata, which is treated as food and herbal medicine in Asia. Itis also found in fruits of Gleditsia sinensis.

Application

Echinocystic acid (EA) may be used for the synthesis of isonorechinocystenedione, via oxidation in the presence of Kiliani′s reagent.

Biochem/physiol Actions

Echinocystic acid is known to possess anti inflammatory property and might be effective in treating cough and bronchitis. Echinocystic acid prevents Hepatitis C virus (HCV) infection by inhibiting viral entry.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

α-Glucosidase and α-amylase inhibitory activities of Pithecellobium dulce bark and leaves.
Katekhaye SD and Nagmoti DM.
Phytopharmacology, 4(1), 123-130 (2013)
Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NFkB and MAPK pathways
Joh EH, et al.
Biochemical Pharmacology, 84(3) (2012)
Xuhui Tong et al.
Biochemical and biophysical research communications, 321(3), 539-546 (2004-09-11)
Echinocystic acid (EA), a natural triterpone enriched in various herbs, has been showed to have cytotoxic activity in some cancer cells, and is used for medicinal purpose in many Asian countries. In the present study, we found that EA could
Elucidation of the pharmacophore of echinocystic acid, a new lead for blocking HCV entry
Wang, H, et al.
European Journal of Medicinal Chemistry, 64(1) (2013)
Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia
Wu J, et al.
Fitoterapia, 81(1) (2010)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service