SMB00608
Potassium clavulanate: silicon dioxide (1:1)
Synonym(s):
Potassium clavulanate: silicon dioxide
form
powder
color
off-white
solubility
water: 1 mg/mL, clear to slightly hazy
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
enzyme | inhibits
storage temp.
2-8°C
General description
Material is a powdered mixture of 1 part potassium clavulanate to 1 part silicon dioxide.
Biochem/physiol Actions
Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.
Packaging
1G
Preparation Note
Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
target_organs
Lungs
supp_hazards
Storage Class
4.2 - Pyrophoric and self-heating hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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B G Spratt et al.
Antimicrobial agents and chemotherapy, 12(3), 406-409 (1977-09-01)
Thienamycin and clavulanic acid are new beta-lactam derivatives with structures markedly different from those of penicillins or cephalosporins. Both derivatives had the same general mode of action as typical beta-lactam antibiotics since they bound to precisely the same proteins as
C Reading et al.
Antimicrobial agents and chemotherapy, 11(5), 852-857 (1977-05-01)
A novel beta-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid. Conditions for the cultivation of the organism and detection and isolation of clavulanic acid are described. This compound resembles the nucleus of
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