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SML0006

CK-666

Name: CK-666
Brand: SIGMA

≥98% (HPLC), powder, Arp2/3 comple inhibitor

Synonym(s):

2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK 666, CK-0944666

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₇FN₂O

CAS Number:

442633-00-3

Molecular Weight:

296.34

UNSPSC Code:

12352200

PubChem Substance ID:

329825083

NACRES:

NA.77

MDL number:

MFCD03036271

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

CK-666, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

SMILES string

Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F

InChI

1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)

InChI key

UXRKUKRXVWJFER-UHFFFAOYSA-N

Description

Application

CK-666 may be used to study Arp2/3-mediated structural changes in cells.

Biochem/physiol Actions

CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.

CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex.

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wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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