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About This Item

Empirical Formula (Hill Notation):
C19H11Cl3N2O4S
CAS Number:
173904-50-2
Molecular Weight:
469.73
UNSPSC Code:
12352200
PubChem Substance ID:
329825099
NACRES:
NA.25
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Assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

COC(=O)\C=C1\SC(=N\C(=O)c2ccc(Cl)cc2Cl)\N(C1=O)c3ccc(Cl)cc3

InChI

1S/C19H11Cl3N2O4S/c1-28-16(25)9-15-18(27)24(12-5-2-10(20)3-6-12)19(29-15)23-17(26)13-7-4-11(21)8-14(13)22/h2-9H,1H3/b15-9+,23-19+

InChI key

SDGLYCKTPKZBGI-MSDDKZNZSA-N

Biochem/physiol Actions

FR-171113 is a Thrombin receptor antagonist
FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
051M4618V
0000084903

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