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Merck
CN

SML0069

NSC 33994

≥98% (HPLC)

Synonym(s):

(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6

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About This Item

Empirical Formula (Hill Notation):
C28H42N2O2
CAS Number:
82058-16-0
Molecular Weight:
438.65
NACRES:
NA.77
PubChem Substance ID:
329825133
UNSPSC Code:
12352200
MDL number:
MFCD20488055

Key Documents

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InChI

1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+

SMILES string

CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2

InChI key

QFNJFVBKASKGEU-OCEACIFDSA-N

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

Application

NSC 33994 may be used in Jak2-mediated cell signaling studies.

Biochem/physiol Actions

NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.
Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000085312
0000040015
061M4619V

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S Khademvatan et al.
Journal of helminthology, 93(2), 131-138 (2018-04-03)
Cystic echinococcosis (CE) caused by Echinococcus granulosus sensu lato (s.l.) is a significant zoonosis, especially in developing countries of the Middle East, with many studies focusing on CE genotypes in Iran. We performed a systematic review to determine the exact
Yuehui Wang et al.
Methods (San Diego, Calif.), 173, 32-43 (2019-06-22)
Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification
Tetsushi Yoshikawa et al.
Journal of medical virology, 91(6), 1008-1013 (2019-01-29)
The main aims of the present study were to elucidate the systemic group A rotavirus (RVA) infection and to clarify the genetic changes of persistent virus in the X-linked severe combined immunodeficiency (SCID) patient. RotaTeq vaccine (RV5) genotype-specific real-time reverse
Kimberly McCoy et al.
ACS nano, 12(4), 3541-3550 (2018-03-21)
Bottom-up construction of mesoscale materials using biologically derived nanoscale building blocks enables engineering of desired physical properties using green production methods. Virus-like particles (VLPs) are exceptional building blocks due to their monodispersed sizes, geometric shapes, production ease, proteinaceous composition, and
Zhen Wang et al.
Scientific reports, 8(1), 9509-9509 (2018-06-24)
The exon junction complex (EJC) deposited on spliced mRNAs, plays a central role in the post-transcriptional gene regulation and specific gene expression. The EJC core complex is associated with multiple peripheral factors involved in various post-splicing events. Here, using recombinant
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