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SML0070

Salsalate

Name: Salsalate
Brand: SIGMA

≥98% (HPLC), COX inhibitor, powder

Synonym(s):

2-(2-Hydroxybenzoyl)oxybenzoic acid, 2-Hydroxybenzoic acid 2-carboxyphenyl ester, disalicylic acid, salicyloxysalicylic acid, salicylsalicylic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₀O₅

CAS Number:

552-94-3

Molecular Weight:

258.23

NACRES:

NA.77

PubChem Substance ID:

329825134

UNSPSC Code:

12352200

EC Number:

209-027-4

MDL number:

MFCD00020252

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Salsalate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

room temp

SMILES string

OC(=O)c1ccccc1OC(=O)c2ccccc2O

InChI

1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)

InChI key

WVYADZUPLLSGPU-UHFFFAOYSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Salsalate was used to study the effect on palmitate-induced insulin resistance and hepatic steatosis in obese rats.

Biochem/physiol Actions

NSAID; Nonacetylated aspirin analog

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H315,H319,H361d,H412

pcodes

P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults.

Corrilynn O Hileman et al.

AIDS (London, England), 24(12), 1958-1961 (2010-07-09)

In this 13-week, open-label, randomized study of the anti-inflammatory salsalate versus usual care, there were no significant improvements in flow-mediated dilation of the brachial artery, endothelial activation, inflammation or coagulation markers, homeostasis model assessment of insulin resistance or lipoproteins with

Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.

Gary L Pierce et al.

Circulation, 119(9), 1284-1292 (2009-02-25)

We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans. We conducted a randomized, double-blind, placebo-controlled crossover study in 14 nondiabetic overweight or obese (body mass index > or =25

Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans.

J M Scheiman et al.

Seminars in arthritis and rheumatism, 20(2), 121-127 (1990-10-01)

Animal models have identified multiple mechanisms of aspirin toxicity. Aspirin inhibits cyclooxygenase in the gastroduodenal mucosa leading to a decrease in endogenous prostaglandins. Prostaglandin mediated mucus and bicarbonate secretion, epithelial hydrophobicity, blood flow, and cellular proliferation are all decreased. Salicylates

Development of a disposable amperometric biosensor for salicylate based on a plastic electrochemical microcell.

R F Carvalhal et al.

Biosensors & bioelectronics, 25(10), 2200-2204 (2010-04-07)

The use of an amperometric biosensor for rapid salicylate determination in blood is described. Photolitography was used to make gold electrodes on a polyester film. The plastic microcell was characterized using cyclic voltammetry to demonstrate the electrochemical performance of the

A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors.

Roberta Noberini et al.

Chemical biology & drug design, 78(4), 667-678 (2011-07-28)

Eph receptor tyrosine kinases and ephrin ligands control many physiological and pathological processes, and molecules interfering with their interaction are useful probes to elucidate their complex biological functions. Moreover, targeting Eph receptors might enable new strategies to inhibit cancer progression

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Global Trade Item Number

SKU	GTIN
SML0070-250MG	04061832786360
SML0070-50MG	04061832786377

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