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Merck
CN

SML0107

Sigma-Aldrich

Pemirolast potassium

≥98% (HPLC)

Synonym(s):

9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt; BMY 26517

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About This Item

Empirical Formula (Hill Notation):
C10H7N6O·K
CAS Number:
100299-08-9
Molecular Weight:
266.30
UNSPSC Code:
12352200
PubChem Substance ID:
329825162
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

light yellow to green-yellow

solubility

H2O: ≥18 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

[K+].CC1=CC=CN2C(=O)C(=CN=C12)c3nnn[n-]3

InChI

1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1

InChI key

NMMVKSMGBDRONO-UHFFFAOYSA-N

Biochem/physiol Actions

Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. It Inhibits chemical mediator release from tissue mast cells and has recently also been shown to inhibit the release of peptides including substance P, neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. It has been used for the treatment of allergic conjunctivitis prophylaxis of for pulmonary hypersensitivity reactions to drugs such as paclitaxel
Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer; Inhibitor of chemical mediator release from tissue mast cells; antiallergic agent

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
081M4714V
0000136603
0000040128

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Jun Li et al.
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 46(1), 43-50 (2010-04-15)
To investigate the cytotoxic effect of three kinds of topical ocular anti-allergic agent, including olopatadine 0.1% (A group), ketotifen fumarate 0.025% (B group) and pemirolast potassium 0.1% (C group), on cultured human corneal epithelial cells in vitro. Primary human corneal
Mayumi Kunitomo et al.
Rhinology, 43(3), 199-204 (2005-10-13)
In the early phase response of allergic rhinitis, the nasal mucosa produces important mediators including histamine and leukotrienes. To investigate the relationship between antigen-induced leukotriene release and histamine secretion in nasal scrapings. Using nasal mucosal scrapings from patients sensitized to
J M Yanni et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 79(6), 541-545 (1998-01-20)
The concept of mast cell heterogeneity is well established. Recent data indicate that human conjunctival tissue mast cells and human connective tissue mast cells respond to various secretagogues in similar fashion. It is now recognized that different mast cell populations
Tomohito Gohda et al.
Arzneimittel-Forschung, 58(1), 18-23 (2008-03-29)
It is still difficult to manage chronic glomerulonephritis with corticosteroids because of safety concerns, especially for patients with mild symptoms and infants. Therefore, an alternative approach is greatly required. Pemirolast potassium (CAS 100299-08-9) is an antiallergic drug with high safety.
D Jin et al.
European journal of pharmacology, 361(2-3), 199-205 (1998-12-29)
N-(3',4'-dimethoxycinnamoyl) anthranilic acid (tranilast), an effective anti-allergic drug, has successfully prevented restenosis in patients who have undergone percutaneous transluminal coronary angioplasty. To elucidate the mechanism of tranilast, we investigated its antagonistic effect to angiotensin II, which plays a pivotal role
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