SML0117
Fosphenytoin disodium salt hydrate
≥98% (HPLC)
Synonym(s):
5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C16H13N2Na2O6P · xH2O
CAS Number:
Molecular Weight:
406.24 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
H2O: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
O.[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI
1S/C16H15N2O6P.2Na.H2O/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;;1H2/q;2*+1;/p-2
InChI key
WPAVXKKGWCHUAK-UHFFFAOYSA-L
Biochem/physiol Actions
Fosphenytoin is a water soluble phenytoin prodrug.
anticonvulsant
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mounzer Y Kassab et al.
Epilepsy research, 87(2-3), 268-271 (2009-10-27)
To study the incidence and extent of the occasionally noted hypotension after intravenous (IV) infusions of fosphenytoin (FOS) and levetiracetam (LEV) in patients presenting with acute cerebral symptoms. Retrospective data collection of consecutive patients with acute cerebral symptoms who received
Kai Eriksson et al.
Expert opinion on drug metabolism & toxicology, 5(6), 695-701 (2009-05-29)
Fosphenytoin, phosphate ester pro-drug of phenytoin, was developed to overcome complications associated with parenteral phenytoin administration in treatment of acute symptomatic seizures, short-term prophylaxis and treatment of repetitive or prolonged seizures and status epilepticus. To evaluate the current position of
Marc P DiFazio et al.
Journal of child neurology, 22(12), 1367-1370 (2008-01-05)
Rotavirus infection is a frequent cause of gastroenteritis in children and accounts for significant morbidity and mortality, especially in the developing world. Less well recognized is the association of rotavirus-induced central nervous system dysfunction, which has been associated with seizure
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0117-5MG | 04061833027196 |
| SML0117-25MG | 04061833027189 |