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Merck
CN

SML0130

Loxiglumide

≥97% (HPLC)

Synonym(s):

4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-pentanoic acid, CR 1505

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About This Item

Empirical Formula (Hill Notation):
C21H30Cl2N2O5
CAS Number:
107097-80-3
Molecular Weight:
461.38
NACRES:
NA.77
PubChem Substance ID:
329825180
UNSPSC Code:
12352200
MDL number:
MFCD00866772

Key Documents

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Product Name

Loxiglumide, ≥97% (HPLC)

InChI key

QNQZBKQEIFTHFZ-UHFFFAOYSA-N

SMILES string

CCCCCN(CCCOC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1

InChI

1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Loxiglumide is a CCK-A receptor antagonist
Loxiglumide is a small-molecule antagonist of the cholecystokinin receptor CCKA. Loxiglumide inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secretions and emptying.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000053621
0000053621
0000017608
0000017607
0000016446

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Yoshifumi Ogura et al.
World journal of surgery, 26(3), 359-365 (2002-02-28)
We evaluated the cholecystokinin (CCK) receptor antagonist loxiglumide (CR1505) for a possible inhibitory effect on biliary carcinogenesis in a hamster model. Experimental group I underwent cholecystoduodenostomy and ligation of the distal end of the common bile duct, after which the
Keiko Shiratori et al.
Pancreas, 25(1), e1-e5 (2002-07-20)
Cholecystokinin (CCK)-receptor antagonists have been found to markedly reduce the severity of pancreatitis and improve survival in experimental animal models of acute pancreatitis. CCK appears to play an important role in the development and progression of acute pancreatitis, and the
Mitsuyoshi Yamamoto et al.
American journal of physiology. Gastrointestinal and liver physiology, 285(4), G681-G687 (2003-06-13)
Recent studies demonstrated that cholecystokinin (CCK) at physiological levels stimulates pancreatic enzyme secretion via a capsaicin-sensitive afferent vagal pathway. This study examined whether chemical ablation of afferent vagal fibers influences pancreatic growth and secretion in rats. Bilateral subdiaphragmatic vagal trunks
Tomasz Brzozowski et al.
The Journal of pharmacology and experimental therapeutics, 310(1), 116-125 (2004-03-17)
Lipopolysaccharide (LPS) is one of the virulence factors in the Helicobacter pylori (Hp)-infected stomach, but it remains unknown whether single and prolonged pretreatment with Hp-LPS can affect the course of gastric damage induced by aspirin (ASA). We compared the effects
D P Hirsch et al.
Alimentary pharmacology & therapeutics, 16(1), 17-26 (2002-02-22)
The oesophago-gastric junction functions as an anti-reflux barrier preventing increased exposure of the oesophageal mucosa to gastric contents. Failure of this anti-reflux barrier results in gastro-oesophageal reflux disease, and may lead to complications such as oesophagitis, Barrett's oesophagus and eventually
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