SML0215
5(S),6(R),7-Trihydroxyheptanoic acid methyl ester
≥98% (HPLC)
Synonym(s):
BML 111
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About This Item
Empirical Formula (Hill Notation):
C8H16O5
CAS Number:
Molecular Weight:
192.21
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: ≥20 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
COC(=O)CCC[C@H](O)[C@H](O)CO
InChI
1S/C8H16O5/c1-13-8(12)4-2-3-6(10)7(11)5-9/h6-7,9-11H,2-5H2,1H3/t6-,7+/m0/s1
InChI key
RNMFWAFZUNVQOR-NKWVEPMBSA-N
Application
5(S),6(R),7-Trihydroxyheptanoic acid methyl ester may be used in lipoxin A receptor-mediated cell signaling studies.
Biochem/physiol Actions
5(S),6(R),7-Trihydroxyheptanoic acid methyl ester is a FRP2/ALX agonist
BML-111 is an analog of the naturally occurring eicosanoid Lipoxin A4. It is an agonist of lipoxin A receptor, also known as formyl peptide receptor 2 (ALX or FPR2). BML-111 potently inhibits cytokine expression and inflammatory cell infiltration in rodent arthritis models, and blocks angiogenesis and tumor growth in hepatic tumor models.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Xia Kong et al.
Experimental and therapeutic medicine, 14(3), 2284-2290 (2017-10-01)
Previous studies have demonstrated that lipoxin A
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