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SML0224

HI-6

Name: HI-6
Brand: SIGMA

≥98% (HPLC), oxime cholinesterase reactivator, powder

Synonym(s):

1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride, 4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride, Asoxime chloride, HI 6, HI 6 chloride, HJ 6, Transant

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₆N₄O₃ · 2Cl

CAS Number:

34433-31-3

Molecular Weight:

359.21

UNSPSC Code:

12352200

PubChem Substance ID:

329825243

NACRES:

NA.77

MDL number:

MFCD00869535

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

HI-6, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 15 mg/mL (clear solution)

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1

InChI

1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H

InChI key

QELSIJXWEROXOE-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

General description

HI-6 functions as an antidote for treating intoxication caused by nerve agents. It acts as a potent drug in radiation protection and suppresses oxidative stress. HI-6 prevents the toxicity of the antineoplastic drug irinotecan.

Biochem/physiol Actions

HI-6 is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure.

HI-6 is an efficient oxime cholinesterase reactivator.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model

Pohanka M, et al.

Neuro Endocrinology Letters, 31(2), 62-62 null

HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model.

Miriam Dadparvar et al.

Toxicology letters, 206(1), 60-66 (2011-07-06)

The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes. However, the blood-brain barrier (BBB) restricts the rapid transport of these drugs from the blood into the brain in therapeutically

A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice.

Jiri Kassa et al.

Basic & clinical pharmacology & toxicology, 110(4), 322-326 (2011-10-11)

The ability of three newly developed reversible inhibitors of acetylcholinesterase (AChE) (K298, K344 and K474) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was compared. Neither

Purity of antidotal oxime HI-6 DMS as an active pharmaceutical ingredient for auto-injectors and infusions.

Reinhard Bogan et al.

Drug testing and analysis, 4(3-4), 199-207 (2012-03-01)

As reactivators of inhibited acetylcholinesterase, oximes are essential antidotes in poisoning by organophosphorus compounds. Due to its superior efficacy in cases of soman, cyclosarin, and sarin poisoning, the oxime HI-6 represents a promising option for an active pharmaceutical ingredient (API)

Investigation of oxidative stress in blood, brain, kidney, and liver after oxime antidote HI-6 application in a mouse experimental model.

Miroslav Pohanka et al.

Drug and chemical toxicology, 34(3), 255-260 (2011-06-09)

Oxime reactivator HI-6 (asoxime, in some sources) is a potent antidote suitable for treatment of intoxication by nerve agents. Despite the fact that HI-6 is considered for practical application in emergency situations, the impact of HI-6 on patients' bodies has

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Global Trade Item Number

SKU	GTIN
SML0224-50MG	04061837077401
SML0224-10MG	04061832075181

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