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Merck
CN

SML0236

ZM 336372

≥98% (HPLC)

Synonym(s):

3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide

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About This Item

Empirical Formula (Hill Notation):
C23H23N3O3
CAS Number:
208260-29-1
Molecular Weight:
389.45
NACRES:
NA.77
PubChem Substance ID:
329825249
UNSPSC Code:
12352200
MDL number:
MFCD02683971

Key Documents

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InChI

1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)

SMILES string

CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2

InChI key

PYEFPDQFAZNXLI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

ZM-336372 is a potent inhibitor of the MAP kinase c-raf in in vitro assay systems (IC50 = 70 nM). In cell-based experiments, ZM-336372 induces c-raf activation through a novel feedback loop in which inhibition is counterbalanced by reactivation.
ZM-336372 is a potent inhibitor of the MAP kinase c-raf.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H413

Hazard Classifications

Aquatic Chronic 4 - Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000089316
042M4726V

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E M Weissinger et al.
British journal of cancer, 91(1), 186-192 (2004-06-10)
Activation of PKA by cAMP agonists, such as 8-Cl-cAMP activation, selectively causes rapid apoptosis in v-abl transformed fibroblasts by inhibiting the Raf-1 kinase. Here we investigated whether 8-Cl-cAMP is useful for the treatment of chronic myelogenous leukaemia (CML), which is

Articles

MAPKKKs

The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.

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