SML0260
ST1936
≥98% (HPLC)
Synonym(s):
2-(5-chloro-2-methyl-1H-indol-3-yl)-N,N-dimethylethanamine
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About This Item
Empirical Formula (Hill Notation):
C13H17ClN2
CAS Number:
Molecular Weight:
236.74
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3
SMILES string
CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12
InChI key
KSYMELKKLOFABL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥5 mg/mL (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
ST1936 is a high affinity 5-HT6-specific agonist (Ki = 13 nM). The IC50 for competition of LSD from 5-HT6 expressed in HEK cells is 40 nM, and the EC50 for stimulating cAMP production is 16 nM.
ST1936 is a serotonin 5-HT6 agonist
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Srijit Das et al.
eLife, 9 (2020-04-24)
Germ cells are vulnerable to stress. Therefore, how organisms protect their future progeny from damage in a fluctuating environment is a fundamental question in biology. We show that in Caenorhabditis elegans, serotonin released by maternal neurons during stress ensures the
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