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SML0300

Aib-1 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

Tyr-Aib-Trp-Phe trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C33H37N5O6 · xC2HF3O2
CAS Number:
1334763-90-4
Molecular Weight:
599.68 (free base basis)
UNSPSC Code:
12352202
PubChem Substance ID:
329825306
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
lyophilized solid
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assay

≥98% (HPLC)

form

lyophilized solid

color

white to beige

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1

InChI key

NELSAMPJZPTPEG-MDQBHWJISA-N

Biochem/physiol Actions

Aib-1 is an inhibitor of β-Amyloid oligomerization.
Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
042M4724V

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Global Trade Item Number

SKUGTIN
SML0300-1MG04061826694114

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