SML0312
Acivicin
≥98% (HPLC)
Synonym(s):
(a-S, 5S)-a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, AT 125, Antibiotic AT 125, NSC 163501, U 42126
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About This Item
Empirical Formula (Hill Notation):
C5H7ClN2O3
CAS Number:
Molecular Weight:
178.57
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1
SMILES string
N[C@@H]([C@@H]1CC(Cl)=NO1)C(O)=O
InChI key
QAWIHIJWNYOLBE-OKKQSCSOSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 10 mg/mL (warmed)
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Acivicin is an antibiotic that inhibits g-glutamyl transpeptidase and transmembrane glutathione transport.
Acivicin is an antibiotic that inhibits g-glutamyl transpeptidase and transmembrane glutathione transport. Acivicin is a potent antitumor agent that induces apoptosis in human lymphoblastoid cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Christianne Bandeira-Melo et al.
The Journal of allergy and clinical immunology, 109(6), 975-979 (2002-06-14)
Eosinophils contain preformed stores of IL-4 within their cytoplasmic granules, but physiologic stimuli to release IL-4 from eosinophils are not yet defined. We evaluated whether cysteinyl leukotrienes (CysLTs) could elicit IL-4 release from eosinophils. We used a dual-antibody capture and
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