SML0316
HZ52
≥98% (HPLC)
Synonym(s):
2-[[4-([1,1′-Biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-octanoic acid
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About This Item
Empirical Formula (Hill Notation):
C24H26ClN3O2S
CAS Number:
Molecular Weight:
456.00
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
ClC1=NC(SC(CCCCCC)C(O)=O)=NC(NC(C=C2)=CC=C2C3=CC=CC=C3)=C1
InChI
1S/C24H26ClN3O2S/c1-2-3-4-8-11-20(23(29)30)31-24-27-21(25)16-22(28-24)26-19-14-12-18(13-15-19)17-9-6-5-7-10-17/h5-7,9-10,12-16,20H,2-4,8,11H2,1H3,(H,29,30)(H,26,27,28)
InChI key
MLNIGXYHGQLWLD-UHFFFAOYSA-N
Biochem/physiol Actions
HZ52 is a dual inhibitor of mPGES and 5-lypoxygenase (Enzyme IC50 = 1.3 and 2.0 mM, respectively). HZ52 inhibits carrageenan-induced pleurisy and PAF-induced lethal shock in mouse.
HZ52 is a dual inhibitor of mPGES and 5-lypoxygenase.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Eleni C Georgiadi et al.
Leukemia & lymphoma, 56(3), 748-754 (2014-06-14)
E2F-1 is the best-described member of the E2F family of transcriptional factors and is particularly interesting in view of its often opposing roles. Our purpose was to examine the immunohistochemical expression of E2F-1 in Hodgkin lymphoma (HL) and to correlate
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0316-25MG | 04061832260952 |
| SML0316-5MG | 04061832786506 |