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Merck
CN

SML0316

HZ52

≥98% (HPLC)

Synonym(s):

2-[[4-([1,1′-Biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-octanoic acid

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About This Item

Empirical Formula (Hill Notation):
C24H26ClN3O2S
CAS Number:
1077626-51-7
Molecular Weight:
456.00
NACRES:
NA.77
PubChem Substance ID:
329825321
UNSPSC Code:
12352200
MDL number:
MFCD28138598

Key Documents

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InChI

1S/C24H26ClN3O2S/c1-2-3-4-8-11-20(23(29)30)31-24-27-21(25)16-22(28-24)26-19-14-12-18(13-15-19)17-9-6-5-7-10-17/h5-7,9-10,12-16,20H,2-4,8,11H2,1H3,(H,29,30)(H,26,27,28)

SMILES string

ClC1=NC(SC(CCCCCC)C(O)=O)=NC(NC(C=C2)=CC=C2C3=CC=CC=C3)=C1

InChI key

MLNIGXYHGQLWLD-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

HZ52 is a dual inhibitor of mPGES and 5-lypoxygenase (Enzyme IC50 = 1.3 and 2.0 mM, respectively). HZ52 inhibits carrageenan-induced pleurisy and PAF-induced lethal shock in mouse.
HZ52 is a dual inhibitor of mPGES and 5-lypoxygenase.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
042M4603V

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Eleni C Georgiadi et al.
Leukemia & lymphoma, 56(3), 748-754 (2014-06-14)
E2F-1 is the best-described member of the E2F family of transcriptional factors and is particularly interesting in view of its often opposing roles. Our purpose was to examine the immunohistochemical expression of E2F-1 in Hodgkin lymphoma (HL) and to correlate

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