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Merck
CN

SML0318

Alvameline tartrate

≥97% (HPLC)

Synonym(s):

2-Ethyl-5-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-2H-tetrazole tartrate, 5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate, Lu 25-109; 3-(2-Ethyl-2H-tetrazol-5-yl)-1,2,5,6-tetrahydro-1-methyl-pyridine tartrate

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About This Item

Empirical Formula (Hill Notation):
C9H15N5 · xC4H6O6
Molecular Weight:
193.25 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825323
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated

Key Documents

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SMILES string

O[C@@H]([C@H](O)C(O)=O)C(O)=O.CCn1nnc(n1)C2=CCCN(C)C2

InChI

1S/C9H15N5.C4H6O6/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8;5-1(3(7)8)2(6)4(9)10/h5H,3-4,6-7H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.0/s1

InChI key

JHGFYOXAUPXDGA-WUUYCOTASA-N

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Alvameline (Lu 25-109) is a muscarinic M1 receptor agonist and M2/M3 receptor antagonist that was under investigation for the treatment of Alzheimer′s disease. Alvameline (Lu 25-109) improved cognitive function following traumatic brain injury (TBI) in rats, but failed to show significant positive results in clinical trials.
Alvameline is a muscarinic M1 receptor agonist.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
062M4701V

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Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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