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Merck
CN

SML0324

JW67

≥98% (HPLC)

Synonym(s):

Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)

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About This Item

Empirical Formula (Hill Notation):
C21H18N2O6
CAS Number:
442644-28-2
Molecular Weight:
394.38
NACRES:
NA.77
PubChem Substance ID:
329825329
UNSPSC Code:
12352200
MDL number:
MFCD03036757

Key Documents

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InChI

1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)

SMILES string

O=C1Nc2ccccc2C13OCC4(CO3)COC5(OC4)C(=O)Nc6ccccc56

InChI key

BTXRSHKJNDFHGA-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

JW67 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo.
JW67 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW67 affects the multiprotein complex consisting of β-catenin/GSK-3b/AXIN/APC/CK1 that controls the degradation of β-catenin. JW67 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000085423
0000042276
042M4612V

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Upasana Sahu et al.
Cell death & disease, 8(3), e2667-e2667 (2017-03-17)
Commensal Escherichia coli has been identified as a major protagonist of microbe-induced colorectal oncogenesis. Its tumour-promoting attribute is linked to the expression of DNA-damaging genotoxins. Using a constitutively invasive variant of non-pathogenic E. coli, we demonstrate that chronic presence of
Azadeh Yeganeh et al.
Biochimica et biophysica acta, 1861(4), 363-370 (2016-01-19)
Trans-10, cis-12 (t10-c12) CLA treatment reduces lipid accumulation in differentiating mouse and human adipocytes, and decreases fat mass in mice, yet the mechanism of action remains unknown. This study investigated the effect of the cis-9, trans-11 (c9-t11) and t10-c12 CLA
Zachary P McKay et al.
Journal of immunology (Baltimore, Md. : 1950), 206(6), 1385-1394 (2021-01-29)
Crosstalk between costimulatory and coinhibitory ligands are a prominent node of immune cell regulation. Mounting evidence points toward a critical role for CD155, the poliovirus receptor, in suppressing T cell function, particularly in cancer. However, relative to other known costimulatory/coinhibitory
Rei Nakano et al.
PloS one, 15(3), e0229892-e0229892 (2020-04-02)
The specification of cell identity depends on the exposure of cells to sequences of bioactive ligands. All-trans retinoic acid (ATRA) affects neuronal development in the early stage, and it is involved in neuronal lineage reprogramming. We previously established a fibroblast-like

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