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SML0358

AA74-1

≥98% (HPLC)

Synonym(s):

[4-(4-Hydroxy-2,6-dimethylheptan-4-yl)-2H-1,2,3-triazol-2-yl](pyrrolidin-1-yl)methanone, [4-[1-Hydroxy-3-methyl-1-(2-methylpropyl)butyl]-2H-1,2,3-triazol-2-yl]-1-pyrrolidinylmethanone

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About This Item

Empirical Formula (Hill Notation):
C16H28N4O2
CAS Number:
1361532-00-4
Molecular Weight:
308.42
NACRES:
NA.77
PubChem Substance ID:
329825360
UNSPSC Code:
12352200
MDL number:
MFCD23704789
Assay:
≥98% (HPLC)
Form:
film
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Quality Segment

assay

≥98% (HPLC)

form

film

color

colorless

solubility

DMSO: >15 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)CC(O)(CC(C)C)c1cnn(n1)C(=O)N2CCCC2

InChI

1S/C16H28N4O2/c1-12(2)9-16(22,10-13(3)4)14-11-17-20(18-14)15(21)19-7-5-6-8-19/h11-13,22H,5-10H2,1-4H3

InChI key

GXBVPGCIMCIASQ-UHFFFAOYSA-N

Biochem/physiol Actions

AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH) with an IC50 of 5 nM in mouse T-cell proteomes. AA74-1 potently blocked the activity of its target serine hydrolase, APEH, in mice in vivo without significantly affecting other enzymes. The APEH inhibition caused accumulation of N-acetylated proteins and stimulated cellular proliferation in T cells.

The APEH gene is deleted in some cancers, in which it has been proposed to serve as a potential tumor suppressor, and is involved in the degradation of oligomeric amyloid-beta which could make it a new target for therapy aimed at reducing neurodegeneration in Alzheimer′s disease. AA74-1 is the first selective tool for studying APEH activity.
AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH).

Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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