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Merck
CN

SML0373

CZC-25146 hydrochloride

≥98% (HPLC)

Synonym(s):

N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H25FN6O4S · HCl
CAS Number:
1435934-18-1
Molecular Weight:
525.00
NACRES:
NA.77
PubChem Substance ID:
329825374
UNSPSC Code:
12352200
MDL number:
MFCD22417347

Key Documents

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InChI key

SKYQTYQDKAOHLP-UHFFFAOYSA-N

SMILES string

Cl.COc1cc(ccc1Nc2ncc(F)c(Nc3ccccc3NS(C)(=O)=O)n2)N4CCOCC4

InChI

1S/C22H25FN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >15 mg/mL (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

CZC-25146 is a potent selective LRRK2 inhibitor.
CZC-25146 is a potent selective and metabolically stable inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson′s disease. Because the most common mutation, G2019S, enhances LRRK2 kinase activity, it is hoped that LRRK2 inhibitors may be useful in treating the disease. CZC-25146 was shown to prevent mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
062M4602V

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