SML0379
Nodinitib-1
≥98% (HPLC)
Synonym(s):
1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, CID-1088438, ML130
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About This Item
Empirical Formula (Hill Notation):
C14H13N3O2S
CAS Number:
Molecular Weight:
287.34
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
NC1=NC2=C(N1S(C3=CC=C(C)C=C3)(=O)=O)C=CC=C2
InChI
1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
InChI key
SRFABRWQVPCPRG-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.
Nodinitib-1 is a selective inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Miao Wang et al.
Journal of neuroinflammation, 17(1), 364-364 (2020-12-03)
Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major factor contributing to the high mortality of intracerebral haemorrhage (ICH). Nucleotide-binding oligomerization domain 1 (NOD1)/receptor-interacting protein 2 (RIP2) signalling has been reported to
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Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to inflammation, but nutrient intake and obesity are also associated with altered bacterial load in metabolic tissues (i.e. metabolic endotoxemia).
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