SML0379
Nodinitib-1
≥98% (HPLC)
Synonym(s):
1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, CID-1088438, ML130
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About This Item
Empirical Formula (Hill Notation):
C14H13N3O2S
CAS Number:
Molecular Weight:
287.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
NC1=NC2=C(N1S(C3=CC=C(C)C=C3)(=O)=O)C=CC=C2
InChI
1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
InChI key
SRFABRWQVPCPRG-UHFFFAOYSA-N
Biochem/physiol Actions
Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.
Nodinitib-1 is a selective inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Miao Wang et al.
Journal of neuroinflammation, 17(1), 364-364 (2020-12-03)
Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major factor contributing to the high mortality of intracerebral haemorrhage (ICH). Nucleotide-binding oligomerization domain 1 (NOD1)/receptor-interacting protein 2 (RIP2) signalling has been reported to
Aram Lee et al.
Journal of ginseng research, 44(2), 300-307 (2020-03-10)
Emerging evidence suggests that endothelial-to-mesenchymal transition (EndMT) in endothelial dysfunction due to persistent inflammation is a key component and emerging concept in the pathogenesis of vascular diseases. Ginsenoside Rg3 (Rg3), an active compound from red ginseng, has been known to
Yi-Hsin Fan et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(48), E7818-E7827 (2016-11-20)
Induction of nucleotide-binding oligomerization domain 2 (NOD2) and downstream receptor-interacting serine/threonine-protein kinase 2 (RIPK2) by human cytomegalovirus (HCMV) is known to up-regulate antiviral responses and suppress virus replication. We investigated the role of nucleotide-binding oligomerization domain 1 (NOD1), which also
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0379-25MG | 04061832633411 |
| SML0379-5MG | 04061832633428 |