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Merck
CN

SML0380

Sigma-Aldrich

FMP-API-1

≥98% (HPLC)

Synonym(s):

3,3′-Diamino-4,4′-dihydroxydiphenylmethane, 4,4′-Methylenebis(2-aminophenol), Bis(3-amino-4-hydroxyphenyl)methane

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About This Item

Empirical Formula (Hill Notation):
C13H14N2O2
CAS Number:
16523-28-7
Molecular Weight:
230.26
MDL number:
MFCD00443347
UNSPSC Code:
12352200
PubChem Substance ID:
329825380
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

Nc1cc(Cc2ccc(O)c(N)c2)ccc1O

InChI

1S/C13H14N2O2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7,16-17H,5,14-15H2

InChI key

KCFVSHSJPIVGCG-UHFFFAOYSA-N

Biochem/physiol Actions

FMP-API-1 is an inhibitor of AKAP-PKA interactions in vitro and in cultured cardiac myocytes that activates PKA. Apparently, FMP-API-1 binds to a novel allosteric regulatory site.
FMP-API-1 is an inhibitor of AKAP-PKA interactions.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air Sensitive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
062M4612V

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Fumiaki Ando et al.
Nature communications, 9(1), 1411-1411 (2018-04-14)
Congenital nephrogenic diabetes insipidus (NDI) is characterized by the inability of the kidney to concentrate urine. Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity. So
Louis-Philippe Bernier et al.
Cell reports, 27(10), 2895-2908 (2019-06-06)
Microglia, the brain's immune cells, maintain homeostasis and sense pathological changes by continuously surveying the parenchyma with highly motile large processes. Here, we demonstrate that microglia also use thin actin-dependent filopodia that allow fast nanoscale sensing within discrete regions. Filopodia

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