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Merck
CN

SML0389

PF-514273

≥98% (HPLC)

Synonym(s):

2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one

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About This Item

Empirical Formula (Hill Notation):
C21H17Cl2F2N3O2
CAS Number:
851728-60-4
Molecular Weight:
452.28
NACRES:
NA.77
PubChem Substance ID:
329825387
UNSPSC Code:
12352202
MDL number:
MFCD12032112

Key Documents

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InChI

1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3

SMILES string

CC(F)(F)CN1CCOc2c(nn(-c3ccccc3Cl)c2-c4ccc(Cl)cc4)C1=O

InChI key

FJMQJSUOOGOWBD-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL (warmed)

storage temp.

−20°C

Biochem/physiol Actions

PF-514273 is a highly selective CB1 antagonist.
PF-514273 is a highly selective CB1 antagonist. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. PF-514273 inhibits food intake and weight gain in rodents.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
062M4724V

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