SML0413
FQI1
≥98% (HPLC)
Synonym(s):
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
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About This Item
Empirical Formula (Hill Notation):
C18H17NO4
CAS Number:
Molecular Weight:
311.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
2-8°C
SMILES string
O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1
InChI
1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)
InChI key
YKSYGLXHLSPWLB-UHFFFAOYSA-N
Biochem/physiol Actions
FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.
FQI1 is an inhibitor of transcription factor LSF.
Storage Class
11 - Combustible Solids
WGK
WGK 3
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