SML0417
Costunolide
≥97% (HPLC), apoptosis inducer, powder
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About This Item
Empirical Formula (Hill Notation):
C15H20O2
CAS Number:
Molecular Weight:
232.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Costunolide, ≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
form
powder
optical activity
[α]/D +110.0 to +130.0°, c = 0.5 in chloroform-d
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
C\C1=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]2CC1
InChI
1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
InChI key
HRYLQFBHBWLLLL-AHNJNIBGSA-N
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General description
Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.
Application
Costunolide has been used to study its effects in allergic asthma using female Balb/c mice and rat basophilic leukemia (RBL)-2H3 mast cells.
Biochem/physiol Actions
Costunolide is a potent inducer of apoptosis and potent anti-cancer agent. Costunolide has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and inhibits telomerase activity.
Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Costunolide: A novel anti Costunolide: A novel anti-cancer sesquiterpene lactone cancer sesquiterpene lactone cancer sesquiterpene lactone
Rasul A, et al.
Bangladesh Journal of Pharmacology, 7, 6-13 (2012)
Ha Si et al.
PloS one, 15(4), e0231466-e0231466 (2020-04-17)
DaHuangWan (DHW) is a traditional herbal medicine used by Mongolian to treat liver cancer for many years. Clinical application of the drug has been shown to help control tumor progression, prolong survival and improve quality of life. However, the underlying
Nobuhiro Ikezawa et al.
The Journal of biological chemistry, 286(24), 21601-21611 (2011-04-26)
Sesquiterpene lactones (STLs) are terpenoid natural products possessing the γ-lactone, well known for their diverse biological and medicinal activities. The occurrence of STLs is sporadic in nature, but most STLs have been isolated from plants in the Asteraceae family. Despite
Azhar Rasul et al.
Molecules (Basel, Switzerland), 18(2), 1418-1433 (2013-01-26)
Despite the availability of several therapeutic options, a safer and more effective modality is urgently needed for treatment of bladder cancer. Costunolide, a member of sesquiterpene lactone family, possesses potent anticancer properties. In this study, for the first time we
Elena Butturini et al.
PloS one, 6(5), e20174-e20174 (2011-06-01)
The main purpose of the present study is to envisage the molecular mechanism of inhibitory action of dehydrocostuslactone (DCE) and costunolide (CS), two naturally occurring sesquiterpene lactones, towards the activation of signal transducer and activator of transcription 3 (STAT3). We
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0417-5MG | 04061837084492 |
| SML0417-25MG | 04061837084485 |
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