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Merck
CN

SML0427

Sigma-Aldrich

Cardionogen-2

≥98% (HPLC)

Synonym(s):

6-(3,4-Dimethoxyphenyl)-3-(2-pyridinyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole, 6-(3,4-Dimethoxyphenyl)-3-pyridin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole, CDNG2, vuc198

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About This Item

Empirical Formula (Hill Notation):
C16H13N5O2S
CAS Number:
578755-52-9
Molecular Weight:
339.37
MDL number:
MFCD04025197
UNSPSC Code:
12352200
PubChem Substance ID:
329825422
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution; warmed)

storage temp.

2-8°C

SMILES string

COc1ccc(cc1OC)-c2nn3c(nnc3s2)-c4ccccn4

InChI

1S/C16H13N5O2S/c1-22-12-7-6-10(9-13(12)23-2)15-20-21-14(18-19-16(21)24-15)11-5-3-4-8-17-11/h3-9H,1-2H3

InChI key

MEWRLQUBVOVSGN-UHFFFAOYSA-N

Biochem/physiol Actions

Cardionogen-2 is a biphasic modulator of cardiogenesis that enlarges the size of the zebrafish embryonic heart by promoting cardiomyocyte formation. Also, cardionogen-2 promotes murine ES cells to differentiate into beating cardiomyocytes. Apparently, cardionogen-2 inhibits Wnt/b-catenin dependent transcriptional activity. Treatment of zebrafish embryos with cardionogen-2 significantly enlarged both the atrium and ventricle, without causing apparent defects of embryonic morphology or other organ development.
Cardionogen-2 is a biphasic modulator of cardiogenesis; inhibits Wnt/β-catenin dependent transcriptional activity.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
072M4620V

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