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SML0434

Gue1654

≥98% (HPLC)

Synonym(s):

7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole

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About This Item

Empirical Formula (Hill Notation):
C23H17N3OS3
CAS Number:
397290-30-1
Molecular Weight:
447.60
NACRES:
NA.77
PubChem Substance ID:
329824717
UNSPSC Code:
12352200
MDL number:
MFCD04419018
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution; warmed)

storage temp.

2-8°C

SMILES string

CSc1nc2ccc3nc(NC(=O)C(c4ccccc4)c5ccccc5)sc3c2s1

InChI

1S/C23H17N3OS3/c1-28-23-25-17-13-12-16-19(20(17)30-23)29-22(24-16)26-21(27)18(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-13,18H,1H3,(H,24,26,27)

InChI key

UFOBDFMYJABXGK-UHFFFAOYSA-N

Biochem/physiol Actions

Gue1654 inhibits signaling of the chemoattractant GPCR 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor (OXE-R), but only signaling involving Gβγ, not Gα signaling triggered upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue1654 is the first small-molecule inhibitor for the oxoeicosanoid receptor and the first to uncouple Gα and Gβγ signaling within a heterotrimer for any GPCR.
Gue1654 is an inhibitor of 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor (OXE-R) signaling involving Gβγ, not Gα.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
082M4715V

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Global Trade Item Number

SKUGTIN
SML0434-25MG04061832786575
SML0434-5MG04061832786582

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