SML0456
HBB2
≥98% (HPLC)
Synonym(s):
(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one
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About This Item
Empirical Formula (Hill Notation):
C17H14O3
CAS Number:
Molecular Weight:
266.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
Oc1ccccc1\C=C\C(=O)\C=C\c2ccccc2O
InChI
1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+
InChI key
YNVAHBUBGBLIEY-WGDLNXRISA-N
Biochem/physiol Actions
HBB2 is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups. Also, HBB2 upregulates Hsp70 in an HSF1-dependent manner. It appears that HBB2 reacts with cysteine residues of KEAP1, which leads to activation of NRF2, and binds to Hsp90 Cys that leads to activation of HST1.
HBB2 is an inducer of the KEAP1/NRF2/ARE pathway, and upregulator of Hsp70.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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International journal of molecular sciences, 21(8) (2020-04-25)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0456-5MG | 04061832633503 |
| SML0456-25MG | 04061832633497 |