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Merck
CN

SML0458

Sigma-Aldrich

Cardionogen-1

≥98% (HPLC)

Synonym(s):

6-Cyclohexyl-3-furan-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole, CDNG1, Cardionogen-1/vuc230

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About This Item

Empirical Formula (Hill Notation):
C13H14N4OS
CAS Number:
577696-37-8
Molecular Weight:
274.34
MDL number:
MFCD04027630
UNSPSC Code:
12352200
PubChem Substance ID:
329824737
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

C1CCC(CC1)c2nn3c(nnc3s2)-c4ccco4

InChI

1S/C13H14N4OS/c1-2-5-9(6-3-1)12-16-17-11(10-7-4-8-18-10)14-15-13(17)19-12/h4,7-9H,1-3,5-6H2

InChI key

SWTUPSNBTSPBIH-UHFFFAOYSA-N

Biochem/physiol Actions

Cardionogen-1 is cardiomyocyte promoter and an inhibitor of Wnt/β-catenin dependent transcription.
Cardionogen-1 is cardiomyocyte promoter and an inhibitor of Wnt/β-catenin dependent transcriptional activity with an EC50 of 23 nM in murine stem cells and zebrafish embryos. It induces cardiac cell formation in both murine stem cells and zebrafish embryos, expanding cardiac progenitor cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
082M4614V

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