SML0458
Cardionogen-1
≥98% (HPLC)
Synonym(s):
6-Cyclohexyl-3-furan-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole, CDNG1, Cardionogen-1/vuc230
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About This Item
Empirical Formula (Hill Notation):
C13H14N4OS
CAS Number:
Molecular Weight:
274.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
InChI
1S/C13H14N4OS/c1-2-5-9(6-3-1)12-16-17-11(10-7-4-8-18-10)14-15-13(17)19-12/h4,7-9H,1-3,5-6H2
SMILES string
C1CCC(CC1)c2nn3c(nnc3s2)-c4ccco4
InChI key
SWTUPSNBTSPBIH-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
2-8°C
Biochem/physiol Actions
Cardionogen-1 is cardiomyocyte promoter and an inhibitor of Wnt/β-catenin dependent transcription.
Cardionogen-1 is cardiomyocyte promoter and an inhibitor of Wnt/β-catenin dependent transcriptional activity with an EC50 of 23 nM in murine stem cells and zebrafish embryos. It induces cardiac cell formation in both murine stem cells and zebrafish embryos, expanding cardiac progenitor cells.
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