SML0464
SPA0355
≥98% (HPLC)
Synonym(s):
N-Methyl-N′-[4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl]-thiourea
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About This Item
Empirical Formula (Hill Notation):
C22H21N3O2S
CAS Number:
Molecular Weight:
391.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C22H21N3O2S/c1-23-22(28)24-16-10-12-17(13-11-16)26-15-14-25-18-6-2-4-8-20(18)27-21-9-5-3-7-19(21)25/h2-13H,14-15H2,1H3,(H2,23,24,28)
SMILES string
CNC(=S)Nc1ccc(OCCN2c3ccccc3Oc4ccccc24)cc1
InChI key
IEFRKIYTMPORCY-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white, to tan to gray
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
2-8°C
Biochem/physiol Actions
SPA0355 inhibits cytokine and LPS-induced activation of NF-kB in cell-based assays, blocking IKK-2 phosphorylation, degradation, and p65 binding to DNA. In vivo, SPA0355 inhibits paw edema and joint destruction in a mouse collagen induced arthritis model.
SPA0355 is a NF-kB pathway inhibitor.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jung-Yeon Kim et al.
Antioxidants (Basel, Switzerland), 9(7) (2020-07-09)
Inflammation and oxidative stress plays an essential role in the pathophysiology of sepsis-associated acute kidney injury (AKI). SPA0355, a thiourea analogue, has been shown to display beneficial effects against a variety of inflammatory diseases arising from its anti-inflammatory and anti-oxidant
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