SML0478
MEL-3 hydrochloride
≥98% (HPLC)
Synonym(s):
5,6-Dihydro-8-(1-methylethyl)-4H-pyrazino[3,2,1-jk]carbazole, 8-(Propan-2-yl)-5,6-dihydro-4H-pyrazino[3,2,1-jk]carbazole hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C17H18N2 · HCl
CAS Number:
Molecular Weight:
286.80
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
MEL-3 is a potent androgen receptor antagonist from a new structural chemical class. MEL-3 has been shown to inhibit the proliferation of both androgen-dependent and androgen-independent AR-positive prostate cancer cell lines. MEL-3 was active against two mutant receptors (AR T877A and ARW741C) that have been found in patients who have become resistant to bicalutamide and hydroxyflutamide, two standard antiandrogens used in prostate cancer therapy.
MEL-3 is a potent androgen receptor antagonist.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0478-5MG | 04061832868066 |
| SML0478-25MG | 04061833033791 |