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Merck
CN

SML0478

MEL-3 hydrochloride

≥98% (HPLC)

Synonym(s):

5,6-Dihydro-8-(1-methylethyl)-4H-pyrazino[3,2,1-jk]carbazole, 8-(Propan-2-yl)-5,6-dihydro-4H-pyrazino[3,2,1-jk]carbazole hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H18N2 · HCl
CAS Number:
292039-18-0
Molecular Weight:
286.80
NACRES:
NA.77
UNSPSC Code:
51111800

Key Documents

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assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

MEL-3 is a potent androgen receptor antagonist from a new structural chemical class. MEL-3 has been shown to inhibit the proliferation of both androgen-dependent and androgen-independent AR-positive prostate cancer cell lines. MEL-3 was active against two mutant receptors (AR T877A and ARW741C) that have been found in patients who have become resistant to bicalutamide and hydroxyflutamide, two standard antiandrogens used in prostate cancer therapy.
MEL-3 is a potent androgen receptor antagonist.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
013M4736V

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Articles

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