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Merck
CN

SML0498

PNU112455A

≥98% (HPLC)

Synonym(s):

4-[(6-amino-4-pyrimidinyl)amino]-benzenesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H11N5O2S · HCl
CAS Number:
21886-12-4
Molecular Weight:
301.75
NACRES:
NA.77
PubChem Substance ID:
329825447
UNSPSC Code:
12352200
MDL number:
MFCD00023272

Key Documents

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InChI

1S/C10H11N5O2S.ClH/c11-9-5-10(14-6-13-9)15-7-1-3-8(4-2-7)18(12,16)17;/h1-6H,(H2,12,16,17)(H3,11,13,14,15);1H

SMILES string

Cl.Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1

InChI key

XBXQRCJKDCEQBS-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

Biochem/physiol Actions

PNU112455A is a CDK 2/5 inhibitor.
PNU112455A is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
102M4611V

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Sholeem Griffin et al.
Biology of reproduction, 99(4), 749-760 (2018-04-25)
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition. Postpartum uterine disease and endometrial pathology in cattle are most associated with the pathogen Trueperella pyogenes.

Articles

Cyclin-dependent Kinases (CDKs)

Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).

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