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Merck
CN

SML0531

BIO-Acetoxime

≥98% (HPLC)

Synonym(s):

(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime, (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one, 6-Bromoindirubin acetoxime, 6-Bromoindirubin-3′-acetoxime, BIA

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About This Item

Empirical Formula (Hill Notation):
C18H12BrN3O3
CAS Number:
667463-85-6
Molecular Weight:
398.21
NACRES:
NA.77
PubChem Substance ID:
329825535
UNSPSC Code:
12352200
MDL number:
MFCD09037533

Key Documents

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InChI

1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+

SMILES string

CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI key

MENDIXKFTXYTHJ-HPBPSMLHSA-N

assay

≥98% (HPLC)

form

powder

color

, dark red to purple

solubility

H2O: 2 mg/mL (clear solution, warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000248335
0000220375
0000220375
0000248335
0000205062

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Ken Ohara et al.
Nephrology (Carlton, Vic.), 24(9), 904-911 (2018-12-24)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic properties. We recently reported that an SGLT2 inhibitor ameliorated extracellular fluid expansion with a transient increase in urinary Na+ excretion. However, the effects of SGLT2 inhibitors on fluid distribution
Xinyan Bi et al.
Nutrients, 10(3) (2018-03-08)
Few studies have been conducted to measure body composition in Asian populations. In this study, we determined the percent body fat (PBF) by using dual-energy X-ray absorptiometry (DEXA), air-displacement plethysmography (ADP or BOD POD), bioelectrical impedance analysis (BIA) and skinfold
Role of Sex Hormones in the Control of Vegetative and Metabolic Functions of Middle-Aged Women.
Vincenzo Monda et al.
Frontiers in physiology, 8, 773-773 (2017-10-20)
Josephine S Jakubowski et al.
Medicine and science in sports and exercise, 51(1), 65-74 (2018-08-17)
Ingestion of proteins with high leucine content during resistance training (RT) can augment hypertrophy. Some data suggest that a leucine metabolite, β-hydroxy, β-methylbutyrate (HMB), is substantially more anabolically efficacious than leucine. We aimed to test whether supplementation with HMB versus
J Casper Swarte et al.
Journal of clinical medicine, 9(2) (2020-02-07)
Renal transplantation is life-changing in many aspects. This includes changes to the gut microbiome likely due to exposure to immunosuppressive drugs and antibiotics. As a consequence, renal transplant recipients (RTRs) might suffer from intestinal dysbiosis. We aimed to investigate the
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肝醣合成酶激酶3 (GSK-3)是一种高度保守的丝氨酸/苏氨酸激酶家族，适于在多种途径中处理100多种蛋白质。查看允许的GSK-3调节剂和相关产品列表。

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